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Genetics Faculty

Visit the Scacheri Lab Website

Peter Scacheri
Ph.D. Training Faculty
Department of Genetics
School of Medicine
Case Western Reserve University
Biomedical Research Building 627
2109 Adelbert Road
Cleveland, Ohio 44106-4955
Tel: (216) 368-3458
Fax: (216) 368-3432

About Peter Scacheri

Peter Scacheri graduated with a BS in Biology from Gettysburg College and earned his Ph.D. in Biochemistry and Molecular Genetics from the University of Pittsburgh. His graduate work was focused on the molecular mechanisms underlying dominantly inherited forms of muscular dystrophy. His postdoctoral fellowship was in the lab of Francis Collins at the National Human Genome Research Institute at the National Institutes of Health. There he combined mouse genetics and genomics to study a type of cancer that affects the endocrine organs. Peter won several awards during his postdoctoral fellowship, including the NHGRI Intramural Research Award for outstanding scientific achievement. In 2006, Peter joined the Case Western Reserve University School of Medicine as an Assistant Professor in Department of Genetics and Genome Sciences, and he is a member of the Case Comprehensive Cancer Center. Peter's research program is focused on understanding the role of epigenetics and the histone code in human health and disease. He has been awarded several NIH grants and he has published more than 40 papers on a broad variety of topics related to genetics, genomics, and bioinformatics. In 2013, Peter was promoted to the level of Associate Professor with tenure.

Selected Publications

Corradin O, Saiakhova A, Akhtar-Zaidi B, Myeroff L, Willis J, Cowper-Sal Lari R, Lupien M, Markowitz S, Scacheri PC (2014)
Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits.
Genome Res;24(1):1-13
See PubMed abstract

Zentner GE, Balow SA, Scacheri PC (2013)
Genomic Characterization of the Mouse Ribosomal DNA Locus.
G3 (Bethesda);:
See PubMed abstract

Balow SA, Pierce LX, Zentner GE, Conrad PA, Davis S, Sabaawy HE, McDermott BM, Scacheri PC (2013)
Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome.
Dev Biol;:
See PubMed abstract

Goodnough LH, Chang AT, Treloar C, Yang J, Scacheri PC, Atit RP (2012)
Twist1 mediates repression of chondrogenesis by β-catenin to promote cranial bone progenitor specification.
See PubMed abstract

Tie F, Banerjee R, Conrad PA, Scacheri PC, Harte PJ (2012)
Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.
Mol Cell Biol;32(12):2323-34
See PubMed abstract

Akhtar-Zaidi B, Cowper-Sal-lari R, Corradin O, Saiakhova A, Bartels CF, Balasubramanian D, Myeroff L, Lutterbaugh J, Jarrar A, Kalady MF, Willis J, Moore JH, Tesar PJ, Laframboise T, Markowitz S, Lupien M, Scacheri PC (2012)
Epigenomic enhancer profiling defines a signature of colon cancer.
See PubMed abstract

Tian C, Yu H, Yang B, Han F, Zheng Y, Bartels CF, Schelling D, Arnold JE, Scacheri PC, Zheng QY (2012)
Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene.
PLoS One;7(4):e34944
See PubMed abstract

Balasubramanian D, Akhtar-Zaidi B, Song L, Bartels CF, Veigl M, Beard L, Myeroff L, Guda K, Lutterbaugh J, Willis J, Crawford GE, Markowitz SD, Scacheri PC (2012)
H3K4me3 inversely correlates with DNA methylation at a large class of non-CpG-island-containing start sites.
Genome Med;4(5):47
See PubMed abstract

Najm FJ, Zaremba A, Caprariello AV, Nayak S, Freundt EC, Scacheri PC, Miller RH, Tesar PJ (2011)
Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells.
Nat Methods;8(11):957-62
See PubMed abstract

Zentner GE, Tesar PJ, Scacheri PC (2011)
Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions.
Genome Res;:
See PubMed abstract

Gabriel E. Zentner, Alina Saiakhova, Pavel Manaenkov, Mark D. Adams, Peter C. Scacheri (2011)
Integrative genomic analysis of human ribosomal DNA
Nucleic Acids Research;doi: 10.1093

Bartels CF, Scacheri C, White L, Scacheri PC, Bale S (2010)
Mutations in the CHD7 Gene: The Experience of a Commercial Laboratory.
Genet Test Mol Biomarkers;14(6):881-91
See PubMed abstract

Tran TH, Jarrell A, Zentner GE, Welsh A, Brownell I, Scacheri PC, Atit R (2010)
Role of canonical Wnt signaling/{beta}-catenin via Dermo1 in cranial dermal cell development.
See PubMed abstract

Zentner GE, Hurd EA, Schnetz MP, Handoko L, Wang C, Wang Z, Wei CL, Tesar PJ, Hatzoglou M, Martin DM, Scacheri PC. (2010)
CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.
Human Molecular Genetics;doi:10.1093

Zentner GE, Layman WS, Martin DM, Scacheri PC (2010)
Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome.
Am J Med Genet A;152A(3):674-686
See PubMed abstract

Schnetz MP, Handoko L, Akhtar-Zaidi B, Bartels CF, Pereira CF, Fisher AG, Adams DJ, Flicek P, Crawford GE, Laframboise T, Tesar P, Wei CL, Scacheri PC (2010)
CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.
PLoS Genet;6(7):e1001023
See PubMed abstract

Balasubramanian D, Scacheri PC (2009)
Functional studies of menin through genetic manipulation of the Men1 homolog in mice.
Adv Exp Med Biol;668:105-15
See PubMed abstract

Tie F, Banerjee R, Stratton CA, Prasad-Sinha J, Stepanik V, Zlobin A, Diaz MO, Scacheri PC, Harte PJ (2009)
CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.
See PubMed abstract

Tao M, Scacheri PC, Marinis JM, Harhaj EW, Matesic LE, Abbott DW (2009)
ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.
Curr Biol;19(15):1255-63
See PubMed abstract

Schnetz MP, Bartels CF, Shastri K, Balasubramanian D, Zentner GE, Balaji R, Zhang X, Song L, Wang Z, Laframboise T, Crawford GE, Scacheri PC (2009)
Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns.
Genome Res;:
See PubMed abstract

Johnson DS, Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, Koch CM, Dunham I, Bieda M, Xu X, Farnham PJ, Kapranov P, Nix DA, Gingeras TR, Zhang X, Holster H, Jiang N, Green RD, Song JS, McCuine SA, Anton E, Nguyen L, Trinklein ND, Ye Z, Ching K, Hawkins D, Ren B, Scacheri PC, Rozowsky J, Karpikov A, Euskirchen G, Weissman S, Gerstein M, Snyder M, Yang A, Moqtaderi Z, Hirsch H, Shulha HP, Fu Y, Weng Z, Struhl K, Myers RM, Lieb JD, Liu XS (2008)
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.
Genome Res;18(3):393-403
See PubMed abstract

Zhang X, Guo C, Chen Y, Shulha HP, Schnetz MP, LaFramboise T, Bartels CF, Markowitz S, Weng Z, Scacheri PC, Wang Z (2008)
Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies.
Nat Methods;5(2):163-5
See PubMed abstract

Agarwal SK, Impey S, McWeeney S, Scacheri PC, Collins FS, Goodman RH, Spiegel AM, Marx SJ (2007)
Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation.
See PubMed abstract

Crawford GE, Davis S,Scacheri PC,Renaud G, Halawi MJ, Erdos MR, Green R, Meltzer PS, Wolfsberg TG, Collins FS. (2006)
DNase-chip: A high resolution method to identify DNaseI hypersensitive sites using tiled microarrays,
Nature Methods;3:503-9
See PubMed abstract

Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS. (2006)
Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.
PLoS Genet.;2(4):e51
See PubMed abstract

Scacheri PC, Crawford GE, Davis S. (2006)
Statistics for ChIP-chip and DNAse hypersensitivity experiments on NimbleGen arrays.
Methods Enzym.;411:270-82
See PubMed abstract

Agarwal SK, Kennedy PA, Scacheri PC, Novotny EA, Hickman AB, Cerrato A, Rice TS, Moore JB, Rao S, Ji Y, Mateo C, Libutti SK, Oliver B, Chandrasekharappa SC, Burns AL, Collins FS, Spiegel AM, Marx SJ. (2005)
Menin molecular interactions: insights into normal functions and tumorigenesis.
Horm Metab Res.;37(6):369-74
See PubMed abstract

Scacheri PC, Crabtree JS, Kennedy AL, Swain GP, Ward JM, Marx SJ, Spiegel AM, Collins FS. (2004)
Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1.
Mamm Genome.;15(11):872-7
See PubMed abstract

Scacheri PC, Kennedy AL, Chin K, Miller MT, Hodgson JG, Gray JW, Marx SJ, Spiegel AM, Collins FS. (2004)
Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability.
Cancer Res.;64(19):7039-44
See PubMed abstract

Agarwal SK, Lee Burns A, Sukhodolets KE, Kennedy PA, Obungu VH, Hickman AB, Mullendore ME, Whitten I, Skarulis MC, Simonds WF, Mateo C, Crabtree JS, Scacheri PC, Ji Y, Novotny EA, Garrett-Beal L, Ward JM, Libutti SK, Richard Alexander H, Cerrato A, Parisi MJ, Santa Anna-A S, Oliver B, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ. (2004)
Molecular pathology of the MEN1 gene.
Ann N Y Acad Sci.;1014:189-98
See PubMed abstract

Scacheri PC, Rozenblatt-Rosen O, Caplen NJ, Wolfsberg TG, Umayam L, Lee JC, Hughes CM, Shanmugam KS, Bhattacharjee A, Meyerson M, Collins FS. (2004)
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells.
Proc Natl Acad Sci U S A.;101(7):1892-7
See PubMed abstract

Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS. (2003)
Of mice and MEN1: Insulinomas in a conditional mouse knockout.
Mol Cell Biol.;23(17):6075-85
See PubMed abstract

Yim SH, Ward JM, Dragan Y, Yamada A, Scacheri PC, Kimura S, Gonzalez FJ. (2003)
Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene e
Toxicol Pathol.;31(3):295-303
See PubMed abstract

Scacheri PC, Gillanders EM, Subramony SH, Vedanarayanan V, Crowe CA, Thakore N, Bingler M, Hoffman EP. (2002)
Novel mutations in collagen VI genes: expansion of the Bethlem myopathy phenotype.
See PubMed abstract

Scacheri PC, Crabtree JS, Novotny EA, Garrett-Beal L, Chen A, Edgemon KA, Marx SJ, Spiegel AM, Chandrasekharappa SC, Collins FS. (2001)
Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice.
See PubMed abstract

Crabtree JS, Scacheri PC, Ward JM, Garrett-Beal L, Emmert-Buck MR, Edgemon KA, Lorang D, Libutti SK, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS. (2001)
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.
Proc Natl Acad Sci U S A.;98(3):1118-23
See PubMed abstract

Scacheri PC, Hoffman EP, Fratkin JD, Semino-Mora C, Senchak A, Davis MR, Laing NG, Vedanarayanan V, Subramony SH. (2000)
A novel ryanodine receptor gene mutation causing both cores and rods in congenital myopathy.
See PubMed abstract

Scacheri PC, Garcia C, Hebert R, Hoffman EP. (1999)
Unique PABP2 mutations in "Cajuns" suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry.
Am J Med Genet.;86(5):477-81
See PubMed abstract

James SW, Bullock KA, Gygax SE, Kraynack BA, Matura RA, MacLeod JA, McNeal KK, Prasauckas KA, Scacheri PC, Shenefiel HL, Tobin HM, Wade SD. (1999)
nimO, an Aspergillus gene related to budding yeast Dbf4, is required for DNA synthesis and mitotic checkpoint control.
J Cell Sci.;112 ( Pt 9):1313-24.
See PubMed abstract

Morrone A, Zammarchi E, Scacheri PC, Donati MA, Hoop RC, Servidei S, Galluzzi G, Hoffman EP. (1997)
Asymptomatic dystrophinopathy.
Am J Med Genet.;69(3):261-7.
See PubMed abstract

Garcia-Heras J, Martin JA, Witchel SF, Scacheri PC. (1997)
De novo der(X)t(X;10)(q26;q21) with features of distal trisomy 10q: case report of paternal origin identified by late replication with BrdU and the human androgen receptor assay (HAR).
J Med Genet;34: 242-245

Hoffman EP, Pegoraro E, Scacheri PC, Burns RG, Taber JW, Weiss L, Spiro A, and Blattner P. (1996)
Genetic counseling of isolated carriers of Duchenne muscular dystrophy.
Am J Med Genet;63: 573-580

James SW, Mirabito PM, Scacheri PC, Morris NR. (1995)
The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.
J Cell Sci.;108 ( Pt 11):3485-99
See PubMed abstract