frame image
frame image

Shawn McCandless
Associate Professor/Director, Center for Human Genetics
Ph.D. Training Faculty
Department of Genetics
School of Medicine
Case Western Reserve University
Biomedical Research Building 622
2109 Adelbert Road
Cleveland, Ohio 44106-4955
Tel: (216) 844-7944
Fax: (216) 368-3432
E-mail: shawn.mccandless@case.edu


About Shawn McCandless

Dr. McCandless earned his M.D. at Temple University and completed Pediatric Residency training at the University of Wisconsin in Madison.

He worked as a Paediatric Registrar in Gloucester, England, then as a general pediatrician at the Northern Navajo Medical Center in Shiprock, NM. He then completed a fellowship in Medical Genetics and Metabolism at Case Western Reserve University before joining the faculty of the Departments of Pediatrics and Genetics at the University of North Carolina - Chapel Hill.

Dr. McCandless is now a member of the Genetics faculty at Case and part of the Center for Human Genetics and the Center for Inherited Disorders of Energy Metabolism.


Research

Dr. McCandless is interested in treatment of genetic disorders, focusing his research primarily on management of inborn errors of metabolism and Prader-Willi syndrome.

Particular attention is paid to developing protocols for managing infants with fatty acid oxidation disorders diagnosed by newborn screening, and to long-term outcomes in those patients.


Selected Publications

Frazier DM, Millington DS, McCandless SE, Koeberl DD, Weavil SD, Chaing SH, Muenzer J. (2006)
The tandem mass spectrometry newborn screening experience in North Carolina: 1997-2005.
J Inherit Metab Dis.;29(1):76-85
See PubMed abstract

Fan H, Booker JK, McCandless SE, Shashi V, Fleming A, Farber RA. (2005)
Mosaicism for an FMR1 gene deletion in a fragile X female.
Am J Med Genet A.;136(2):214-7
See PubMed abstract

Quigley DI, Sailus J, Kaiser-Rogers K, Rao KW, Calikoglu M, Gold S, McCandless SE. (2005)
A clinical report of a patient with two abnormal cell lines: 46,XX,del(21)(q22.1) and 47,XX,+3.
Am J Med Genet A.;132(1):101-5
See PubMed abstract

O'Reilly L, Bross P, Corydon TJ, Olpin SE, Hansen J, Kenney JM, McCandless SE, Frazier DM, Winter V, Gregersen N, Engel PC, Andresen BS. (2004)
The Y42H mutation in medium-chain acyl-CoA dehydrogenase, which is prevalent in babies identified by MS/MS-based newborn screening, is temperature sensitive.
Eur J Biochem.;271(20):4053-63.
See PubMed abstract

McCandless SE. (2004)
A primer on expanded newborn screening by tandem mass spectrometry.
Prim Care;583-604, ix-x
See PubMed abstract

McCandless SE, Brunger JW, Cassidy SB. (2004)
The burden of genetic disease on inpatient care in a children's hospital.
Am J Hum Genet.;74(1):121-7.
See PubMed abstract

Harvey Mudd S, Braverman N, Pomper M, Tezcan K, Kronick J, Jayakar P, Garganta C, Ampola MG, Levy HL, McCandless SE, Wiltse H, Stabler SP, Allen RH, Wagner C, Borschel MW. (2003)
Infantile hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trap.
Mol Genet Metab.;79(1):6-16.
See PubMed abstract

Koeberl DD, Millington DS, Smith WE, Weavil SD, Muenzer J, McCandless SE, Kishnani PS, McDonald MT, Chaing S, Boney A, Moore E, Frazier DM. (2003)
Evaluation of 3-methylcrotonyl-CoA carboxylase deficiency detected by tandem mass spectrometry newborn screening.
J Inherit Metab Dis.;26(1):25-35.
See PubMed abstract

Holve S, Hu D, McCandless SE. (2001)
Metachromatic leukodystrophy in the Navajo: fallout of the American-Indian wars of the nineteenth century.
Am J Med Genet.;101(3):203-8.
See PubMed abstract

Andresen BS, Dobrowolski SF, O'Reilly L, Muenzer J, McCandless SE, Frazier DM, Udvari S, Bross P, Knudsen I, Banas R, Chace DH, Engel P, Naylor EW, Gregersen N. (2001)
Medium-chain acyl-CoA dehydrogenase (MCAD) mutations identified by MS/MS-based prospective screening of newborns differ from those observed in patients with clinical symptoms: identification and chara
Am J Hum Genet.;68(6):1408-18.
See PubMed abstract

Chadwick LH, McCandless SE, Silverman GL, Schwartz S, Westaway D, Nadeau JH. (2000)
Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes.
Genomics.;70(1):66-73.
See PubMed abstract

McCandless SE, Schwartz S, Morrison S, Garlapati K, Robin NH. (2000)
Adult with an interstitial deletion of chromosome 10 [del(10)(q25. 1q25.3)]: overlap with Coffin-Lowry syndrome.
Am J Med Genet.;95(2):93-8.
See PubMed abstract