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Genetics Faculty


Guangbin Luo
Associate Professor
Ph.D. Training Faculty
Department of Genetics
School of Medicine
Case Western Reserve University
Biomedical Research Building 636
2109 Adelbert Road
Cleveland, Ohio 44106-4955
Tel: (216) 368-4883
Fax: (216) 368-3432
E-mail: guangbin.luo@case.edu


About Guangbin Luo

Dr. Luo graduated in Molecular Genetics in 1993 from the University of Illinois at Urbana-Champaign. He became a postdoctoral fellow at University of Texas MD Anderson Cancer Center in 1993, and then a Research Associate in Dr. Allan Bradley at the Howard Hughes Medical Institute at Baylor College of Medicine in 1996.

He is the recipients of the Howard Temin Award from the National Cancer Institute in 2000, the Basil O'Connor Starter Scholar Award from the March of Dimes Foundation in 2001, and the Searle Scholar Award in 2001.

He has served as an Associate Editor for the journal of Current Genomics since 1999.

Dr. Luo joined the Department of Genetics and the Ireland Cancer Center at CWRU and University Hospitals of Cleveland in May, 2000.


Research

My laboratory use mouse to model human diseases and to conduct other aspect of genetic studies, including gene identification.

We are currently using knockout mouse models to study a unique class of human syndromes that are caused by mutations in RecQ DNA helicase homologues.

Defects in RecQ DNA helicase homologues in these human syndromes have led to genomic instability and cancer predisposition and a great variety of other abnormalities.

We are particularly interested in studying how defects in individual RecQ helicase can lead to specific disease phenotypes in these distinct yet similar syndromes. A mouse model for both Bloom and Rothmund-Thomson syndromes are now being studied in the laboratory.

We are also continuing to further develop the Sleeping Beauty (SB) transposon as an insertional mutagen for mouse genetic study. The SB transposon is the only known active DNA transposon in mice. We are currently using this transposon system to set up transposon-tagged mutagenesis strategies for phenotype-driven genetic screens in mice to identify novel candidates genes for cancer as well as other human diseases.


Selected Publications

Recql5 Plays an Important Role in DNA Replication and Cell Survival Following Camptothecin Treatment.
Hu Y, Lu X, Zhou G, Barnes EL, Luo G
Mol Biol Cell (2008);:
See PubMed abstract

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G
Genes Dev (2007);:
See PubMed abstract

Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis.
Merkulov S, Zhang WM, Komar AA, Schmaier AH, Barnes E, Zhou Y, Lu X, Iwaki T, Castellino FJ, Luo G, McCrae KR
Blood (2007);:
See PubMed abstract

A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators.
Zhu H, Hasman RA, Barron VA, Luo G, Lou H
Mol Biol Cell (2006);17(12):5105-14
See PubMed abstract

15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Myung SJ, Rerko RM, Yan M, Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G, Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD
Proc Natl Acad Sci U S A (2006);103(32):12098-102
See PubMed abstract

Inhibition of multiple gene expression and virus replication of HBV by stable RNA interference in 2.2.15 cells.
Ren X, Luo G, Xie Z, Zhou L, Kong X, Xu A
J Hepatol (2006);44(4):663-70
See PubMed abstract

Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers.
Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G
Mol Cell Biol (2005);25(9):3431-42
See PubMed abstract

Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.
Mann MB, Hodges CA, Barnes E, Vogel H, Hassold TJ, Luo G
Hum Mol Genet (2005);14(6):813-25
See PubMed abstract

15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.
Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JK, Luo G, Hensold J, Tai HH, Wilson K, Markowitz SD
Proc Natl Acad Sci U S A (2004);101(50):17468-73
See PubMed abstract

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.
Du X, Shen J, Kugan N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pignolo RJ, DePinho RA, Guarente L, Johnson FB
Mol Cell Biol (2004);24(19):8437-46
See PubMed abstract

Cancer predisposition caused by elevated mitotic recombination in Bloom mice.
Luo G, Santoro IM, McDaniel LD, Nishijima I, Mills M, Youssoufian H, Vogel H, Schultz RA, Bradley A.
Nat Genet. (2000);26(4):424-9.
See PubMed abstract

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ
Genes Dev (2000);14(12):1448-59
See PubMed abstract

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation.
Luo G, Yao MS, Bender CF, Mills M, Bladl AR, Bradley A, Petrini JH.
Proc Natl Acad Sci U S A. (1999);96(13):7376-81.
See PubMed abstract

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells.
Luo G, Ivics Z, Izsvak Z, Bradley A.
Proc Natl Acad Sci U S A. (1998);95(18):10769-73.
See PubMed abstract

Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.
Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G
Nature (1997);386(6620):78-81
See PubMed abstract

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.
Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G
Genes Dev (1995);9(22):2808-20
See PubMed abstract