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Genetics Faculty

Shih-Hsing Leir
Assistant Professor
Department of Genetics
School of Medicine
Case Western Reserve University
Biomedical Research Building 722
2109 Adelbert Road
Cleveland, Ohio 44106-4955
Tel: (216) 368-6418
Fax: (216) 368-3432

About Shih-Hsing Leir


Cystic fibrosis (CF) is an inherited disease that affects multiple organs, including reproductive system. At least 97% of men with CF are infertile, in most cases due to congenital bilateral absence of the vas deferens (CBAVD). However, duct obstruction in CF is not the only reason for male infertility, suggesting that cystic fibrosis transmembrane conductance regulator (CFTR) plays an important role in production and maturation of sperm. My current study uses primary cultures of human epididymis epithelial cells and developed three-dimensional culture models to address how CFTR regulates normal tubule function in the epididymis. My goals are to understand the mechanisms of CFTR and other ion channels regulated epithelial function and tubulogenesis in the human epididymis.

Selected Publications

Region-specific innate antiviral responses of the human epididymis.
Browne JA, Leir SH, Eggener SE, Harris A
Mol Cell Endocrinol (2018);473:72-78
See PubMed abstract

A transcription factor network represses CFTR gene expression in airway epithelial cells.
Mutolo MJ, Leir SH, Fossum SL, Browne JA, Harris A
Biochem J (2018);475(7):1323-1334
See PubMed abstract

HNF1 regulates critical processes in the human epididymis epithelium.
Browne JA, Yang R, Eggener SE, Leir SH, Harris A
Mol Cell Endocrinol (2016);425:94-102
See PubMed abstract

Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions.
Browne JA, Yang R, Leir SH, Eggener SE, Harris A
Mol Hum Reprod (2016);22(2):69-82
See PubMed abstract

Characterization of primary cultures of adult human epididymis epithelial cells.
Leir SH, Browne JA, Eggener SE, Harris A
Fertil Steril (2015);103(3):647-54.e1
See PubMed abstract