About Ronald Conlon
Ron was a student at the University of Western Ontario and McGill University in Canada, and The University of Texas at Austin. He was a postdoctoral fellow in Janet Rossant's laboratory in Toronto. Ron joined the Department of Genetics in 1994.
Research
The Conlon lab focusses on the mechanisms of early development. Axis formation, segmentation and pattern formation are studied with embryological, molecular and genetic techniques.
The early development of mammals is poorly understood, in part because of the lack of evolutionary conservation of these processes. The genes and mechanisms governing cleavage, implantation, axis formation and segmentation are studied by means which allow us to uncover the relevant genes in these processes.
The function of the genes on mouse chromosome 2 in early development are studied through the engineering of mutations, and multiple gene deletions. Gene targeting, site-specific recombinases, and chemical mutagens are used to reveal the role of these genes.
Learn more about the lab, the research and the people at the Conlon lab web site: conlonlab.org
Selected Publications
| Cui Y, Niziolek PJ, Macdonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, Zambrowicz B, Gerrits H, Gossen JA, He X, Bader M, Williams BO, Warman ML, Robling AG (2011) |
| Lrp5 functions in bone to regulate bone mass. |
| Nat Med;: |
| See PubMed abstract |
| Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, Kingston RE, Gusella JF, Conlon RA, MacDonald ME (2010) |
| Huntingtin facilitates polycomb repressive complex 2. |
| Hum Mol Genet;19(4):573-83 |
| See PubMed abstract |
| Atit, R., Sgaier, S. K., Mohamed, O.A., Taketo, M. M., Dufort, D., Joyner, A. L., Niswander, L. and Conlon, R. A. (2006) |
| beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. |
| Dev Biol;296(1):164-76 |
| See PubMed abstract |
| Atit R, Sgaier SK, Mohamed OA, Taketo MM, Dufort D, Joyner AL, Niswander L, Conlon RA (2006) |
| ß-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse |
| Dev Biol;296(1):164-76 |
| See PubMed abstract |
| LePage, D. F., and Conlon, R. A. (2006) |
| Animal Models for Disease: Knockout,Knock-In and Conditional Mutant Mice |
| Methods Mol Med;129:41-67 |
| See PubMed abstract |
| Hakimi, P., Croniger, C. M., Johnson, M., Yang, J., LePage, D. F., Conlon, R. A., Kalhan, S. C., Reshef, L., Tilghman, S. C. and Hanson, R. W. (2005) |
| Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism. |
| Nutr Metab (Lond).;2:33 |
| See PubMed abstract |
| Scott, M. M., Wylie, C. J., Lerch, J. K., Herlitze, S., Jiang, W., Conlon, R. A., Strowbridge, B. W. and Deneris, E. S. (2005) |
| A genetic approach to access serotonin neurons for in vivo and in vitro studies |
| Proc. Natl Acad Sci U S A;102(45):16472-7 |
| See PubMed abstract |
| Woda, J. M., Calzonetti, T., Hilditch-Maquire, P., Duyao, M P.,
Conlon, R. A., MacDonald, M. E. (2005) |
| Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo |
| BMC Dev Biol;5:17 |
| See PubMed abstract |
| Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD (2004) |
| A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development |
| Blood;104(10):3097-105 |
| See PubMed abstract |
| McCallion, A.S., Stames, E., Conlon, R.A. and Chakravarti, A. (2003) |
| Phenotype variation in two-locus mouse models of Hirschsprung disease: tissue-specific interaction between Ret and Ednrb |
| Proc. Nat. Acad. Sci. USA;100(4):1826-31 |
| See PubMed abstract |
| Atit, R., Conlon, R.A. and Niswander, L. (2003) |
| EGF signaling patterns the feather array by promoting the interbud fate |
| Dev. Cell;4(2):231-40 |
| See PubMed abstract |
| Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Conlon RA, Hoit BD, Watanabe M, Yang YC (2002) |
| Essential role of Cited2, a negative regulator of HIF1-, in heart development and neurulation |
| Proc Natl Acad Sci U S A;99(16):10488-93 |
| See PubMed abstract |
| Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D (2002) |
| Notch pathway molecules are essential for the maintenance but not the generation of mammalian neural stem cells |
| Genes Dev;16(7):846-58 |
| See PubMed abstract |
| Dunwoodie SL, Clements M, Sparrow DB, Sa X, Conlon RA, Beddington RS (2002) |
| Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm |
| Development;129(7):1795-806 |
| See PubMed abstract |
| Tucker KE, Berciano MT, Jacobs EY, LePage DF, Shpargel KB, Rossire JJ, Chan EK, Lafarga M, Conlon RA, Matera AG (2001) |
| Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the Spinal Muscular Atrophy gene product |
| J Cell Biol;154(2):293-307 |
| See PubMed abstract |
| LePage, D. F., Church, D. M., Millie, E., Hassold, T. J. and Conlon, R. A. (2000) |
| Rapid generation of nested chromosomal deletions on mouse chromosome 2 |
| Proc Natl Acad Sci U S A;97(19):10471-6 |
| See PubMed abstract |
| Barrantes IB, Elia AJ, Wunsch K, Hrabe de Angelis MH, Mak TW, Rossant J, Conlon RA, Gossler A, de la Pompa JL (1999) |
| Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse |
| Current Biology;9(9):470-80 |
| See PubMed abstract |
