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Ronald Conlon
Associate Professor
Ph.D. Training Faculty
Department of Genetics
School of Medicine
Case Western Reserve University
Biomedical Research Building 623
2109 Adelbert Road
Cleveland, Ohio 44106-4955
Tel: (216) 368-1826
Fax: (216) 368-3432
E-mail: ronald.conlon@case.edu
http://knockout.cwru.edu/


About Ronald Conlon

Ron was a student at the University of Western Ontario and McGill University in Canada, and The University of Texas at Austin. He was a postdoctoral fellow in Janet Rossant's laboratory in Toronto. Ron joined the Department of Genetics in 1994.


Research

The Conlon lab focusses on the mechanisms of early development. Axis formation, segmentation and pattern formation are studied with embryological, molecular and genetic techniques.

The early development of mammals is poorly understood, in part because of the lack of evolutionary conservation of these processes. The genes and mechanisms governing cleavage, implantation, axis formation and segmentation are studied by means which allow us to uncover the relevant genes in these processes. The function of the genes on mouse chromosome 2 in early development are studied through the engineering of mutations, and multiple gene deletions. Gene targeting, site-specific recombinases, and chemical mutagens are used to reveal the role of these genes. Learn more about the lab, the research and the people at the Conlon lab web site: conlonlab.org


Selected Publications

Cui Y, Niziolek PJ, Macdonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, Zambrowicz B, Gerrits H, Gossen JA, He X, Bader M, Williams BO, Warman ML, Robling AG (2011)
Lrp5 functions in bone to regulate bone mass.
Nat Med;:
See PubMed abstract

Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, Kingston RE, Gusella JF, Conlon RA, MacDonald ME (2010)
Huntingtin facilitates polycomb repressive complex 2.
Hum Mol Genet;19(4):573-83
See PubMed abstract

Atit, R., Sgaier, S. K., Mohamed, O.A., Taketo, M. M., Dufort, D., Joyner, A. L., Niswander, L. and Conlon, R. A. (2006)
beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse.
Dev Biol;296(1):164-76
See PubMed abstract

Atit R, Sgaier SK, Mohamed OA, Taketo MM, Dufort D, Joyner AL, Niswander L, Conlon RA (2006)
ß-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
Dev Biol;296(1):164-76
See PubMed abstract

LePage, D. F., and Conlon, R. A. (2006)
Animal Models for Disease: Knockout,Knock-In and Conditional Mutant Mice
Methods Mol Med;129:41-67
See PubMed abstract

Hakimi, P., Croniger, C. M., Johnson, M., Yang, J., LePage, D. F., Conlon, R. A., Kalhan, S. C., Reshef, L., Tilghman, S. C. and Hanson, R. W. (2005)
Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism.
Nutr Metab (Lond).;2:33
See PubMed abstract

Scott, M. M., Wylie, C. J., Lerch, J. K., Herlitze, S., Jiang, W., Conlon, R. A., Strowbridge, B. W. and Deneris, E. S. (2005)
A genetic approach to access serotonin neurons for in vivo and in vitro studies
Proc. Natl Acad Sci U S A;102(45):16472-7
See PubMed abstract

Woda, J. M., Calzonetti, T., Hilditch-Maquire, P., Duyao, M P., Conlon, R. A., MacDonald, M. E. (2005)
Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo
BMC Dev Biol;5:17
See PubMed abstract

Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD (2004)
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development
Blood;104(10):3097-105
See PubMed abstract

McCallion, A.S., Stames, E., Conlon, R.A. and Chakravarti, A. (2003)
Phenotype variation in two-locus mouse models of Hirschsprung disease: tissue-specific interaction between Ret and Ednrb
Proc. Nat. Acad. Sci. USA;100(4):1826-31
See PubMed abstract

Atit, R., Conlon, R.A. and Niswander, L. (2003)
EGF signaling patterns the feather array by promoting the interbud fate
Dev. Cell;4(2):231-40
See PubMed abstract

Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Conlon RA, Hoit BD, Watanabe M, Yang YC (2002)
Essential role of Cited2, a negative regulator of HIF1-, in heart development and neurulation
Proc Natl Acad Sci U S A;99(16):10488-93
See PubMed abstract

Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D (2002)
Notch pathway molecules are essential for the maintenance but not the generation of mammalian neural stem cells
Genes Dev;16(7):846-58
See PubMed abstract

Dunwoodie SL, Clements M, Sparrow DB, Sa X, Conlon RA, Beddington RS (2002)
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm
Development;129(7):1795-806
See PubMed abstract

Tucker KE, Berciano MT, Jacobs EY, LePage DF, Shpargel KB, Rossire JJ, Chan EK, Lafarga M, Conlon RA, Matera AG (2001)
Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the Spinal Muscular Atrophy gene product
J Cell Biol;154(2):293-307
See PubMed abstract

LePage, D. F., Church, D. M., Millie, E., Hassold, T. J. and Conlon, R. A. (2000)
Rapid generation of nested chromosomal deletions on mouse chromosome 2
Proc Natl Acad Sci U S A;97(19):10471-6
See PubMed abstract

Barrantes IB, Elia AJ, Wunsch K, Hrabe de Angelis MH, Mak TW, Rossant J, Conlon RA, Gossler A, de la Pompa JL (1999)
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
Current Biology;9(9):470-80
See PubMed abstract