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Genetics Faculty


Ronald Conlon
Associate Professor
Ph.D. Training Faculty
Department of Genetics
School of Medicine
Case Western Reserve University
Biomedical Research Building 623
2109 Adelbert Road
Cleveland, Ohio 44106-4955
Tel: (216) 368-1826
Fax: (216) 368-3432
E-mail: ronald.conlon@case.edu
http://knockout.cwru.edu/


About Ronald Conlon

Ron was a student at the University of Western Ontario and McGill University in Canada, and The University of Texas at Austin. He was a postdoctoral fellow in Janet Rossant's laboratory in Toronto. Ron joined the Department of Genetics in 1994. He became Director of the Case Transgenic and Targeting Facility in 2001.


Research

Ron has pursued fundamental mechanisms in development including the mechanisms of vertebrate segmentation and patterning. His current research focuses on gene editing and animal models for somatic gene therapies.


Selected Publications

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.
Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, Conlon RA, Markowitz S, Kinzler KW, Velculescu VE, Brunengraber H, Willis JE, LaFramboise T, Hatzoglou M, Zhang GF, Vogelstein B, Wang Z
Nat Commun (2016);7:11971
See PubMed abstract

Lrp5 functions in bone to regulate bone mass.
Cui Y, Niziolek PJ, Macdonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, Zambrowicz B, Gerrits H, Gossen JA, He X, Bader M, Williams BO, Warman ML, Robling AG
Nat Med (2011);:
See PubMed abstract

Huntingtin facilitates polycomb repressive complex 2.
Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, Kingston RE, Gusella JF, Conlon RA, MacDonald ME
Hum Mol Genet (2010);19(4):573-83
See PubMed abstract

beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse.
Atit, R., Sgaier, S. K., Mohamed, O.A., Taketo, M. M., Dufort, D., Joyner, A. L., Niswander, L. and Conlon, R. A.
Dev Biol (2006);296(1):164-76
See PubMed abstract

Animal Models for Disease: Knockout,Knock-In and Conditional Mutant Mice
LePage, D. F., and Conlon, R. A.
Methods Mol Med (2006);129:41-67
See PubMed abstract

Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism.
Hakimi, P., Croniger, C. M., Johnson, M., Yang, J., LePage, D. F., Conlon, R. A., Kalhan, S. C., Reshef, L., Tilghman, S. C. and Hanson, R. W.
Nutr Metab (Lond). (2005);2:33
See PubMed abstract

A genetic approach to access serotonin neurons for in vivo and in vitro studies
Scott, M. M., Wylie, C. J., Lerch, J. K., Herlitze, S., Jiang, W., Conlon, R. A., Strowbridge, B. W. and Deneris, E. S.
Proc. Natl Acad Sci U S A (2005);102(45):16472-7
See PubMed abstract

Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo
Woda, J. M., Calzonetti, T., Hilditch-Maquire, P., Duyao, M P., Conlon, R. A., MacDonald, M. E.
BMC Dev Biol (2005);5:17
See PubMed abstract

A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development
Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD
Blood (2004);104(10):3097-105
See PubMed abstract

Phenotype variation in two-locus mouse models of Hirschsprung disease: tissue-specific interaction between Ret and Ednrb
McCallion, A.S., Stames, E., Conlon, R.A. and Chakravarti, A.
Proc. Nat. Acad. Sci. USA (2003);100(4):1826-31
See PubMed abstract

EGF signaling patterns the feather array by promoting the interbud fate
Atit, R., Conlon, R.A. and Niswander, L.
Dev. Cell (2003);4(2):231-40
See PubMed abstract

Essential role of Cited2, a negative regulator of HIF1-, in heart development and neurulation
Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Conlon RA, Hoit BD, Watanabe M, Yang YC
Proc Natl Acad Sci U S A (2002);99(16):10488-93
See PubMed abstract

Notch pathway molecules are essential for the maintenance but not the generation of mammalian neural stem cells
Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D
Genes Dev (2002);16(7):846-58
See PubMed abstract

Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm
Dunwoodie SL, Clements M, Sparrow DB, Sa X, Conlon RA, Beddington RS
Development (2002);129(7):1795-806
See PubMed abstract

Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the Spinal Muscular Atrophy gene product
Tucker KE, Berciano MT, Jacobs EY, LePage DF, Shpargel KB, Rossire JJ, Chan EK, Lafarga M, Conlon RA, Matera AG
J Cell Biol (2001);154(2):293-307
See PubMed abstract

Rapid generation of nested chromosomal deletions on mouse chromosome 2
LePage, D. F., Church, D. M., Millie, E., Hassold, T. J. and Conlon, R. A.
Proc Natl Acad Sci U S A (2000);97(19):10471-6
See PubMed abstract

Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
Barrantes IB, Elia AJ, Wunsch K, Hrabe de Angelis MH, Mak TW, Rossant J, Conlon RA, Gossler A, de la Pompa JL
Current Biology (1999);9(9):470-80
See PubMed abstract