Graduate Students:

Victoria Barron, started in July 2005
	victoria.barron@case.edu Research focus: CELF and MBLN protein-mediated splicing regulation Funding: Developmental Biology NIH training grant (2006-2008); Predoctoral Fellowship, American Heart Association (2008-2010)
Publications: Zhu H, Hasman RA, Barron VA, Luo G and Lou H (2006) A Nuclear Function of Hu Proteins as Neuron-Specific Alternative RNA Processing Regulators. Mol. Biol. Cell. 17: 5105. Barron VA, Zhu H, Hinman MN, Ladd AN and Lou H (2010) The Neurofibromatosis Type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation. Nucl Acids Res. 38:253. Zhou H-L, Hinman MN, Barron VA, Geng C, Zhou G, Luo G, Siegel RE, Lou H (2011) Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner. Proc Natl Acad Sci U S A. 2011 Aug 1. [Epub ahead of print] Barron VA and Lou H (2011) Alternative splicing of the Neurofibromatosis type I pre-mRNA. Biosci Rep. In press.
Melissa Hinman, started in July 2006
	melissa.hinman@case.edu Research focus: Biological role of NF1 alternative splicing; domain analysis of HuC protein Funding: Genetics NIH training grant (2007-2009); Predoctoral Fellowship, NINDS National Research Service Award (2010-2012)
Pulications: Zhu H, Hinman MN., Hasman RA, Mehta P. and Lou H (2008) Regulation of neuron-specific alternative splicing of neurofibromatosis type 1 pre-mRNA. Mol. Cell. Biol. 28:1240. Hinman MN and Lou H (2008). Diverse molecular functions of Hu proteins. Cell. Mol. Life Sci. 65:3168. Barron VA, Zhu H, Hinman MN, Ladd AN and Lou H (2010) The Neurofibromatosis Type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation. Nucl Acids Res. 38:253. Zhou H-L, Hinman MN, Barron VA, Geng C, Zhou G, Luo G, Siegel RE, Lou H (2011) Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner. Proc Natl Acad Sci U S A. 2011 Aug 1. [Epub ahead of print]
Hieu Nguyen, started in July 2010
	hieu.t.nguyen@case.edu Research focus: Epigenetic regulation of alternative splicing Funding: Vietnam Education Foundation (2010-current)

Postdoctoral Fellows:

Hua-Lin Zhou, Ph.D., started in July 2005
	hualin.zhou@case.edu Research focus: Fox-1/Fox-2 protein-mediated splicing regulation; coupling of transcription and splicing mediated by Hu proteins; regulation of Hu protein activities. Funding: Postdoctoral Fellowship, American Heart Association (2007-2010)
Publications: Zhu H, Zhou H-L, Hasman RA and Lou H (2007) Hu proteins regulate polyadenylation by blockingsites containing U rich sequences. J. Biol. Chem. 282:2203. Zhou H-L, Baraniak AP and Lou H (2007) Involvement of Fox-1/Fox-2 in the coordinated regulation of calcitonin/CGRP alternative RNA processing. Mol. Cell. Biol. 27: 830. Zhou H-L and Lou H (2008) Repression of Pre-spliceosomal Complex Formation at Two Distinct Steps? by Fox-1/Fox-2 Proteins. Mol Cell Biol. 28:5507. Zhou H-L, Hinman MN, Barron VA, Geng C, Zhou G, Luo G, Siegel RE, Lou H (2011) Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner. Proc Natl Acad Sci U S A. 2011 Aug 1. [Epub ahead of print]
Alok Sharma, Ph.D., started in April 2011
	alok.sharma@case.edu Research focus: Biological role of NF1 alternative splicing in heart development; regulation of Hu protein activities.

Research Associates:

Cuiyu Geng, Ph.D. started in September 2009
	cuiyu.geng@case.edu
Publications: Zhou H-L, Hinman MN, Barron VA, Geng C, Zhou G, Luo G, Siegel RE, Lou H (2011) Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner. Proc Natl Acad Sci U S A. 2011 Aug 1. [Epub ahead of print]

Undergraduate Students:

Past Members

Graduate Students:

	Hui Zhu, M.D., Ph.D. In the lab: 2001-2007 Funding: Predoctoral Fellowship, American Heart Association (2004-2006) Hui received the Harold Weintraub Graduate Student Award in 2007
Current address: Department of Medicine Long Island Jewish Medical Center 270-05 76th Avenue New Hyde Park, NY 11040 hzhu@nshs.edu Publications: Zhu H, Hasman RA, Young KM, Kedersha NL and Lou H (2003) ?U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. ?Mol Cell Biol. 17:5959. Zhu H, Hasman RA, Barron,VA, Luo G and Lou H (2006) A Nuclear Function of Hu Proteins as Neuron-Specific Alternative RNA Processing Regulators. Mol. Biol. Cell. 17: 5105. Zhu H, Zhou H, Hasman RA and Lou H (2007) Hu proteins regulate polyadenylation by blockingsites containing U rich sequences. J. Biol. Chem. 282:2203. Zhu H, Hinman MN, Hasman RA, Mehta P and Lou H (2008) Regulation of neuron-specific alternative splicing of neurofibromatosis type 1 pre-mRNA. Mol. Cell. Biol. 28:1240. Barron VA, Zhu H, Hinman MN, Ladd AN and Lou H (2010) The Neurofibromatosis Type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation. Nucl Acids Res. 38:253. Wang H, Molfenter A, Zhu H, Hasman RA and Lou H (2010) Positive regulation of exon inclusion of HuD pre-mRNA by Hu proteins. Nucl Acids Res. 38: 3760.
	Jill Molfenter, M.S. In the lab: July 2004-June 2006
Pulications: Wang H, Molfenter A, Zhu H, Hasman RA and Lou H (2010) Positive regulation of exon inclusion of HuD pre-mRNA by Hu proteins. Nucl Acids Res. 38: 3760.
	Ivana Ninkovic, M.P.H., started in July 2009 In the lab: July 2009-December 2010 Funding: Genetics NIH training grant (2009-2010)

Postdoctoral Fellows:

	Huiwen Wang, Ph.D., started in October 2007 Current Position: Associate Professor Institute of Biophysics Chinese Academy of Sciences Beijing, China gj28@ibp.ac.cn Research focus: Hu/CELF protein-mediated splicing regulation
Pulications: Wang H, Molfenter A, Zhu H, Hasman RA and Lou H (2010) Positive regulation of exon inclusion of HuD pre-mRNA by Hu proteins. Nucl Acids Res. 38: 3760.

Research Assistants:

	Robert Hasman, B.S., M.B.A. In the Lab: July 2002-December 2007 robert.hasman@att.net
Publications: Zhu H, Hasman RA, Young KM, Kedersha NL and Lou H (2003) ?U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. ?Mol Cell Biol. 17:5959. Zhu H, Hasman RA, Barron,VA, Luo G and Lou H (2006) A Nuclear Function of Hu Proteins as Neuron-Specific Alternative RNA Processing Regulators. Mol. Biol. Cell. 17: 5105. Zhu H, Zhou H-L, Hasman RA and Lou H (2007) Hu proteins regulate polyadenylation by blockingsites containing U rich sequences. J. Biol. Chem. 282:2203. Zhu H, Hinman MN, Hasman RA, Mehta P and Lou H (2008) Regulation of neuron-specific alternative splicing of neurofibromatosis type 1 pre-mRNA. Mol. Cell. Biol. 28:1240. Wang H, Molfenter A, Zhu H, Hasman RA and Lou H (2010) Positive regulation of exon inclusion of HuD pre-mRNA by Hu proteins. Nucl Acids Res. 38: 3760.
	Katherine Young, M.D. In the lab: July 2000-June 2002 Kate received an M.D. degree from Case Western Reserve University in 2006
Pulications: Zhu H, Hasman RA, Young KM, Kedersha NL and Lou H (2003) ?U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. ?Mol Cell Biol. 17:5959.

Undergraduate Students: